Unmet needs in severe asthma
Significant unmet needs exist in severe asthma, such as persistent exacerbations, hospitalisations and symptoms contributing to poor quality of life.2
EpiDashboard
Welcome to the EpiDashboard! Explore key learning content related to epithelial science, meet the team of experts who have co-created this platform and visit our Resource Library for downloadable content and supporting resources. If you’d like to hear more from us about upcoming events and new content, please register for an EpiCentral account.
RegisterMeet the EpiCreators
Find out more about the team of international leading experts who have co-created the EpiCentral website and its content.
View the EpiCreator biogsDiscover the EpiFundamentals
In this section you can learn more about the challenges and complexity of severe asthma and explore the role of the epithelium and epithelial cytokines in the inflammatory cascade.
Learn more about the challenges in severe asthmaCongress highlights: EAACI 2022
Read our highlights from the EAACI 2022 meeting in Prague, including key takeaways and a summary of latest data shared
Download highlightsEPIFUNDAMENTALS
Article
Article
Complexity of severe asthma
Overlapping and changing inflammatory pathways in response to an exacerbation, trigger or treatment change highlight the complexity of severe asthma.1–4
Article
Role of the epithelium in asthma
The airway epithelium is the first point of contact for environmental triggers, and initiates inflammation and structural changes that contribute to asthma.1–3
Epithelial cytokines (TSLP, IL-33, IL-25) are released in response to triggers, initiating a cascade of immune responses that drive clinical features of asthma.1–5
In addition to his clinical practice and teaching, Professor Boulet’s research aims to establish links between basic research and clinical science in the field of asthma and respiratory allergy.
Professor Louis-Philippe Boulet, MD, FRCPC
Professor of Medicine, Department of Medicine, Laval University
SCIENTIFIC AND RESOURCE LIBRARY
Explore our curated library of materials to support and extend the ‘EpiFundamentals’ modules. Access latest research insights and download helpful assets to support your understanding of epithelial science. Remember to check back as the library will be updated regularly.
Summary of the EpiFundamental modules; this slide deck aims to highlight the central role of the airway epithelium.
Professor Porsbjerg and Professor Boulet explore how the epithelial cytokines drive airway inflammation and airway hyperresponsiveness in asthma.
Slide deck summarising the involvement of the epithelial cytokines in asthma.
Video
The inflammatory cascade
An overview of how IL-33, TSLP and
IL-25 drive inflammation via effects on various types of immune cells.
An explanation of the increased expression of alarmins in patients with asthma, and the resultant production of downstream cytokines by effector immune cells.
A summary of how the airway epithelium drives pathophysiological changes and the heterogeneous symptoms in patients with asthma.
An overview of how TSLP interacts with mast cells contributing to airway hyperresponsiveness.
A summary of how damage to the epithelium drives inflammatory responses via the release of alarmins.
Images from the asthma mechanism of disease video – the role of the epithelial cytokines in asthma.
The role of epithelial cytokines in asthma.