EpiDashboard

Welcome to the EpiDashboard. Explore key learning content related to the ‘EpiFundamentals’ modules and meet the team of experts who have co-created this resource. Register for an account now to personalise your EpiDashboard and access additional supporting assets within our ‘Scientific and Resource Library’.

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Meet the EpiCreators

Find out more about the team of international leading experts who have co-created the EpiCentral website and its content.

View the EpiCreator biogs

Discover the EpiFundamentals

In this section you can learn more about the challenges and complexity of severe asthma and explore the role of the epithelium and epithelial cytokines in the inflammatory cascade.

Learn more about the challenges in severe asthma

Airway hyperresponsiveness

Airway hyperresponsivenes is an intricate interplay of airway inflammation, airway remodeling1 and airway smooth muscle hypercontractility.2

Find out more about airway hyperresponsiveness

EPIFUNDAMENTALS

Featured EpiArticle Unmet needs in severe asthma
Article

Unmet needs in severe asthma

Significant unmet needs exist in severe asthma, such as persistent exacerbations, hospitalisations and symptoms contributing to poor quality of life.2  

Overlapping and changing inflammatory pathways in response to an exacerbation, trigger or treatment change highlight the complexity of severe asthma.1–4

The airway epithelium is the first point of contact for environmental triggers, and initiates inflammation and structural changes that contribute to asthma.1–3

Epithelial cytokines (TSLP, IL-33, IL-25) are released in response to triggers, initiating a cascade of immune responses that drive clinical features of asthma.1–5  

Airway hyperresponsiveness is an intricate interplay of airway inflammation, airway remodeling1 and airway smooth muscle hypercontractility.2 

SCIENTIFIC AND RESOURCE LIBRARY

Explore our curated library of materials to support and extend the ‘EpiFundamentals’ modules. Access latest research insights and download helpful assets to support your understanding of epithelial science. Remember to check back as the library will be updated regularly.

Professor Ian Pavord discussing the role of epithelial cytokines in a patient case study involving a patient with allergic asthma and an allergic trigger. 

Professor Chris Brightling describes the role of epithelial cytokines in the inflammatory asthma pathway. 

Learn more about the science behind how epithelial cytokines drive clinical features of asthma.

Infographic summarising the unmet needs in severe asthma. 

Infographic summarising the inflammatory pathways in asthma.

Infographic summarising the consequences of suboptimal asthma control.

Slide deck outlining the burden and remaining unmet need in severe asthma.

Learn more about the science behind how epithelial cytokines drive clinical features of asthma.

Infographic highlighting the central role of the airway epithelium in asthma-related inflammation

An infographic displaying the overlapping and changing pathways in patients with severe asthma.